Assessment of Autonomic Nervous System in Children with Celiac Disease: A heart rate variability study

Kayali S, Selbuz S.Indian Pediatr. 2020 May 6:S097475591600176. Online ahead of print.PMID: 32376794



Objective: We evaluated the activity of autonomic nervous system in children with celiac disease by using heart rate variability (HRV) analysis.

Methods: HRV parameters of 37 children with celiac disease were compared to 36 age and sex matched healthy controls. None of the participants had a systemic, central or peripheral neurological disease.

Results: Statistically significant differences were present in two parameters; standard deviation of all RR intervals (SDNN) and standard deviation of 5-minute RR interval means (SDANN). Age was negatively correlated with mean, minimum and maximum heart rate. Duration of disease was positively correlated with low frequency power-high frequency power ratio. No correlation was found between anti-tissue transglutaminase IgA level and HRV parameters.

Conclusion: Celiac disease may affect autonomic nervous function in children even if there are no symptoms of dysautonomia.