Cardiovascular complications in patients with Turner’s syndrome

Kostopoulou E, Bosdou JK, Anagnostis P, Stevenson JC, Goulis DG.Curr Pharm Des. 2020 May 31. doi: 10.2174/1381612826666200531152459. Online ahead of print.PMID: 32473616



Turner’s or Turner syndrome (TS) is the most prevalent chromosomal abnormality in female live births. Patients with TS are predisposed to increased risk of cardiovascular disease (CVD), mainly due to the frequently observed congenital structural cardiovascular defects, such as valvular and aortic abnormalities (coarctation, dilatation and dissection). The increased prevalence of cardiometabolic risk factors, such as arterial hypertension, insulin resistance, diabetes mellitus, dyslipidaemia, central obesity and increased carotid intima-media thickness, also contribute to increased morbidity and mortality in TS patients. Menopausal hormone therapy (MHT) is the treatment of choice, combined with growth hormone (GH). Although MHT may, in general, ameliorate CVD risk factors, its effect on CVD mortality in TS has not yet been established. The exact effect of GH on these parameters has not yet been clarified. Specific consideration should be provided in TS cases during pregnancy, due to the higher risk of CVD complications, such as aortic dissection. Optimal cardiovascular monitoring, including physical examination, electrocardiogram, CVD risk factor assessment and transthoracic echocardiography is recommended. Moreover, cardiac magnetic resonance from the age of 12 years is recommended due to the high risk of aortic aneurysm and other anatomical vascular complications.