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TBX4 variants and pulmonary diseases: getting out of the ‘Box’

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Uncertainty of Prenatally Diagnosed Congenital Heart Disease: A Qualitative Study

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Fetal Cardiac Function and Ventricular Volumes Determined by Three-Dimensional Ultrasound Using STIC and VOCAL Methods in Fetuses from Pre-gestational Diabetic Women

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Novel mutations of the SRF gene in Chinese sporadic conotruncal heart defect patients

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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ADAMTS19-associated heart valve defects: Novel genetic variants consolidating a recognizable cardiac phenotype

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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A call for innovation in fetal monitoring during fetal surgery

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Second heart field-specific expression of Nkx2-5 requires promoter proximal interaction with Srf

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Role of Tafazzin in Mitochondrial Function, Development and Disease

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Uncertainty of Prenatally Diagnosed Congenital Heart Disease: A Qualitative Study

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Telocytes in the Myocardium of Children with Congenital Heart Disease Tetralogy of Fallot

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Hypermethylation-mediated down-regulation of lncRNA TBX5-AS1:2 in Tetralogy of Fallot inhibits cell proliferation by reducing TBX5 expression

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Prenatal diagnosis and pregnancy outcomes of 1492 fetuses with congenital heart disease: role of multidisciplinary-joint consultation in prenatal diagnosis

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Normal human and sheep fetal vessel oxygen saturations by T2 magnetic resonance imaging

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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New and advanced features of fetal intelligent navigation echocardiography (FINE) or 5D heart

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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15q11.2 deletion is enriched in patients with total anomalous pulmonary venous connection

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Implementation of a statewide, multisite fetal tele-echocardiography program: evaluation of more than 1100 fetuses over 9 years

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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COngenital heart disease and the Diagnostic yield with Exome sequencing (CODE Study): prospective cohort study and systematic review

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Impact of standardized prenatal documentation among newborns with ductal-dependent heart disease

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Can Circulating Cardiac Biomarkers Be Helpful in the Assessment of LMNA Mutation Carriers?

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Genetics of atrioventricular canal defects

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Knockdown of Long Non-Coding RNA AFAP1-AS1 Promoted Viability and Suppressed Death of Cardiomyocytes in Response to I/R In Vitro and In Vivo

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Identification of KIAA0196 as a novel susceptibility gene for myofibril structural disorganization in cardiac development

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Association Between MTHFR C677T Polymorphism and Congenital Heart Disease

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Fetal Speckle-Tracking: Impact of Angle of Insonation and Frame Rate on Global Longitudinal Strain

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Notch1 signaling mediated dysfunction of bone marrow mesenchymal stem cells derived from cyanotic congenital heart disease

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Proteomics analysis of plasma protein changes in patent ductus arteriosus patients

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Effects of PM 2.5 exposure in utero on heart injury, histone acetylation and GATA4 expression in offspring mice

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Transforming Growth Factor Beta3 is Required for Cardiovascular Development

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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Uncertainty of Prenatally Diagnosed Congenital Heart Disease: A Qualitative Study

Jul 26, 2020 | Fetal Cardiology and Genetics

Hansmann G, Koestenberger M, Alastalo TP, Apitz C, Austin ED, Bonnet D, Budts W, D'Alto M, Gatzoulis MA, Hasan BS, Kozlik-Feldmann R, Kumar RK, Lammers AE, Latus H, Michel-Behnke I, Miera O, Morrell NW, Pieles G, Quandt D, Sallmon H, Schranz D, Tran-Lundmark K, Tulloh...

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TBX4 variants and pulmonary diseases: getting out of the ‘Box’

Jul 26, 2020 | Fetal Cardiology and Genetics

Haarman MG, Kerstjens-Frederikse WS, Berger RMF.Curr Opin Pulm Med. 2020 May;26(3):277-284. doi: 10.1097/MCP.0000000000000678.PMID: 32195678 Free PMC article.   Abstract Purpose of review: In 2013, the association between T-Box factor 4 (TBX4) variants and...

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Uncertainty of Prenatally Diagnosed Congenital Heart Disease: A Qualitative Study

Jul 26, 2020 | Fetal Cardiology and Genetics

Harris KW, Brelsford KM, Kavanaugh-McHugh A, Clayton EW.JAMA Netw Open. 2020 May 1;3(5):e204082. doi: 10.1001/jamanetworkopen.2020.4082.PMID: 32369178 Free PMC article.   Abstract Importance: Parents who receive a prenatal diagnosis of congenital heart disease...

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Fetal Cardiac Function and Ventricular Volumes Determined by Three-Dimensional Ultrasound Using STIC and VOCAL Methods in Fetuses from Pre-gestational Diabetic Women

Jul 26, 2020 | Fetal Cardiology and Genetics

Bravo-Valenzuela NJ, Peixoto AB, Mattar R, Melo Júnior JF, da Silva Pares DB, Araujo Júnior E.Pediatr Cardiol. 2020 May 4. doi: 10.1007/s00246-020-02362-7. Online ahead of print.PMID: 32367304   Abstract To assess the fetal cardiac function and ventricular...

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Novel mutations of the SRF gene in Chinese sporadic conotruncal heart defect patients

Jul 26, 2020 | Fetal Cardiology and Genetics

Mengmeng X, Yuejuan X, Sun C, Yanan L, Fen L, Kun S.BMC Med Genet. 2020 May 7;21(1):95. doi: 10.1186/s12881-020-01032-y.PMID: 32380971 Free PMC article.   Abstract Background: Conotruncal heart defects (CTDs) are a group of congenital heart malformations that...

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ADAMTS19-associated heart valve defects: Novel genetic variants consolidating a recognizable cardiac phenotype

Jul 26, 2020 | Fetal Cardiology and Genetics

Massadeh S, Alhashem A, van de Laar IMBH, Alhabshan F, Ordonez N, Alawbathani S, Khan S, Kabbani MS, Chaikhouni F, Sheereen A, Almohammed I, Alghamdi B, Frohn-Mulder I, Ahmad S, Beetz C, Bauer P, Wessels MW, Alaamery M, Bertoli-Avella AM.Clin Genet. 2020...

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A call for innovation in fetal monitoring during fetal surgery

Jul 26, 2020 | Fetal Cardiology and Genetics

Warner LL, Arendt KW, Ruano R, Qureshi MY, Segura LG.J Matern Fetal Neonatal Med. 2020 May 19:1-7. doi: 10.1080/14767058.2020.1767575. Online ahead of print.PMID: 32429715   Abstract Purpose: A growing number of fetal procedures are performed at specialized fetal...

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Second heart field-specific expression of Nkx2-5 requires promoter proximal interaction with Srf

Jul 26, 2020 | Fetal Cardiology and Genetics

Clark CD, Lee KH.Mech Dev. 2020 May 22:103615. doi: 10.1016/j.mod.2020.103615. Online ahead of print.PMID: 32450132 Abstract The cardiac homeobox transcription factor Nkx2-5 is a major determinant of cardiac identity and cardiac morphogenesis. Nkx2-5 operates as part...

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Role of Tafazzin in Mitochondrial Function, Development and Disease

Jul 26, 2020 | Fetal Cardiology and Genetics

Chin MT, Conway SJ.J Dev Biol. 2020 May 23;8(2):E10. doi: 10.3390/jdb8020010.PMID: 32456129 Review.   Abstract Tafazzin, an enzyme associated with the rare inherited x-linked disorder Barth Syndrome, is a nuclear encoded mitochondrial transacylase that is highly...

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Uncertainty of Prenatally Diagnosed Congenital Heart Disease: A Qualitative Study

Jul 26, 2020 | Fetal Cardiology and Genetics

Harris KW, Brelsford KM, Kavanaugh-McHugh A, Clayton EW.JAMA Netw Open. 2020 May 1;3(5):e204082. doi: 10.1001/jamanetworkopen.2020.4082.PMID: 32369178 Free PMC article.   Abstract Importance: Parents who receive a prenatal diagnosis of congenital heart disease...

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Telocytes in the Myocardium of Children with Congenital Heart Disease Tetralogy of Fallot

Jul 26, 2020 | Fetal Cardiology and Genetics

Sukhacheva TV, Nizyaeva NV, Samsonova MV, Chernyaev AL, Shchegolev AI, Serov RA.Bull Exp Biol Med. 2020 May;169(1):137-146. doi: 10.1007/s10517-020-04840-7. Epub 2020 Jun 2.PMID: 32488790   Abstract Telocytes, a new type of interstitial stem cells with long thin...

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Hypermethylation-mediated down-regulation of lncRNA TBX5-AS1:2 in Tetralogy of Fallot inhibits cell proliferation by reducing TBX5 expression

Jul 26, 2020 | Fetal Cardiology and Genetics

Ma J, Chen S, Hao L, Sheng W, Chen W, Ma X, Zhang B, Ma D, Huang G.J Cell Mol Med. 2020 May 5. doi: 10.1111/jcmm.15298. Online ahead of print.PMID: 32368852 Free article.   Abstract Tetralogy of Fallot (TOF) is the most common complex congenital heart disease...

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Prenatal diagnosis and pregnancy outcomes of 1492 fetuses with congenital heart disease: role of multidisciplinary-joint consultation in prenatal diagnosis

Jul 26, 2020 | Fetal Cardiology and Genetics

Qiu X, Weng Z, Liu M, Chen X, Wu Q, Ling W, Ma H, Huang H, Lin Y.Sci Rep. 2020 May 5;10(1):7564. doi: 10.1038/s41598-020-64591-3.PMID: 32371943 Free PMC article.   Abstract Early diagnosis of congenital heart disease (CHD) can improve the prognosis of neonates...

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Normal human and sheep fetal vessel oxygen saturations by T2 magnetic resonance imaging

Jul 26, 2020 | Fetal Cardiology and Genetics

Saini BS, Darby JRT, Portnoy S, Sun L, van Amerom J, Lock MC, Soo JY, Holman SL, Perumal SR, Kingdom JC, Sled JG, Macgowan CK, Morrison JL, Seed M.J Physiol. 2020 May 5. doi: 10.1113/JP279725. Online ahead of print.PMID: 32372463 Abstract Key points: Human fetal...

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New and advanced features of fetal intelligent navigation echocardiography (FINE) or 5D heart

Jul 26, 2020 | Fetal Cardiology and Genetics

Yeo L, Romero R.J Matern Fetal Neonatal Med. 2020 May 6:1-19. doi: 10.1080/14767058.2020.1759538. Online ahead of print.PMID: 32375528   Abstract Congenital heart disease (CHD) is the leading organ-specific birth defect, as well as the leading cause of infant...

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15q11.2 deletion is enriched in patients with total anomalous pulmonary venous connection

Jul 26, 2020 | Fetal Cardiology and Genetics

Li X, Shi G, Li Y, Zhang X, Xiang Y, Wang T, Li Y, Chen H, Fu Q, Zhang H, Wang B.J Med Genet. 2020 May 6:jmedgenet-2019-106608. doi: 10.1136/jmedgenet-2019-106608. Online ahead of print.PMID: 32376791   Abstract Introduction: CNV is a vital pathogenic factor of...

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