Performance of risk models predicting cardiac complications in pregnant women with congenital heart disease: a meta-analysis

Wang TKM, Lowe B, Hlohovsky S, O’Donnell C.
Intern Med J. 2020 Apr;50(4):481-484. doi: 10.1111/imj.14810.
PMID: 32270622
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Accurate risk stratification is important in pregnant women including the growing population with congenital heart disease (CHD). We meta-analysed the performance of risk models for CHD women. Six studies with 3426 pregnancies were studied, with cardiac complication rates of 6.7-20.6%. Pooled c-statistics (95% confidence interval) for scores were mWHO 0.71 (0.65-0.76), CARPREG 0.66 (0.61-0.71) and ZAHARA 0.71 (0.65-0.76). Current risk models had at best moderate discrimination for CHD women with significant room for improvement.