ACHD December 2021 Abstracts

Smoking among adult congenital heart disease survivors in the United States: Prevalence and relationship with illness perceptions.

Fox KR, Hardy RY, Moons P, Kovacs AH, Luyckx K, Apers S, Cook SC, Veldtman G, Fernandes SM, White K, Kutty S, Jackson JL; APPROACH-IS Consortium and the International Society for Adult Congenital Heart Disease (ISACHD).J Behav Med. 2021 Dec;44(6):772-783. doi: 10.1007/s10865-021-00239-5. Epub 2021 Jun 29.PMID: 34185220

Heterogeneity of Treatment Effects in an Analysis of Pooled Individual Patient Data From Randomized Trials of Device Closure of Patent Foramen Ovale After Stroke.

Kent DM, Saver JL, Kasner SE, Nelson J, Carroll JD, Chatellier G, Derumeaux G, Furlan AJ, Herrmann HC, Jüni P, Kim JS, Koethe B, Lee PH, Lefebvre B, Mattle HP, Meier B, Reisman M, Smalling RW, Soendergaard L, Song JK, Mas JL, Thaler DE.JAMA. 2021 Dec 14;326(22):2277-2286. doi: 10.1001/jama.2021.20956.PMID: 34905030

Difficult Endotracheal Intubation in Adult Congenital Heart Disease Patients.

Houska N, Ing RJ, Chatterjee D.J Cardiothorac Vasc Anesth. 2021 Dec;35(12):3665-3666. doi: 10.1053/j.jvca.2021.08.031. Epub 2021 Aug 26.PMID: 34521581 No abstract available.

Usefulness of cardiac fusion imaging with computed tomography and Doppler echocardiography in the assessment of conduit stenosis in complex adult congenital heart disease.

Watanabe N, Toh N, Takaya Y, Nakayama R, Yokohama F, Osawa K, Miyoshi T, Akagi T, Kanazawa S, Ito H.J Cardiol. 2021 Dec;78(6):473-479. doi: 10.1016/j.jjcc.2021.06.008. Epub 2021 Jul 12.PMID: 34266716

Arrhythmias in adults with congenital heart disease and heart failure.

Bessière F, Mondésert B, Chaix MA, Khairy P.Heart Rhythm O2. 2021 Dec 17;2(6Part B):744-753. doi: 10.1016/j.hroo.2021.10.005. eCollection 2021 Dec.PMID: 34988526

Evolution of echocardiography in adult congenital heart disease: from pulsed-wave Doppler to fusion imaging.

Toh N, Akagi T, Kasahara S, Ito H.J Echocardiogr. 2021 Dec;19(4):205-211. doi: 10.1007/s12574-021-00533-w. Epub 2021 May 28.PMID: 34047950 Review.

Study design and rationale of the pAtients pResenTing with cOngenital heaRt dIseAse Register (ARTORIA-R).

Sinning C, Zengin E, Diller GP, Onorati F, Castel MA, Petit T, Chen YS, Lo Rito M, Chiarello C, Guillemain R, Coniat KN, Magnussen C, Knappe D, Becher PM, Schrage B, Smits JM, Metzner A, Knosalla C, Schoenrath F, Miera O, Cho MY, Bernhardt A, Weimann J, Goßling A, Terzi A, Amodeo A, Alfieri S, Angeli E, Ragni L, Napoleone CP, Gerosa G, Pradegan N, Rodrigus I, Dumfarth J, de Pauw M, François K, Van Caenegem O, Ancion A, Van Cleemput J, Miličić D, Moza A, Schenker P, Thul J, Steinmetz M, Warnecke G, Ius F, Freyt S, Avsar M, Sandhaus T, Haneya A, Eifert S, Saeed D, Borger M, Welp H, Ablonczy L, Schmack B, Ruhparwar A, Naito S, Hua X, Fluschnik N, Nies M, Keil L, Senftinger J, Ismaili D, Kany S, Csengeri D, Cardillo M, Oliveti A, Faggian G, Dorent R, Jasseron C, Blanco AP, Márquez JMS, López-Vilella R, García-Álvarez A, López MLP, Rocafort AG, Fernández ÓG, Prieto-Arevalo R, Zatarain-Nicolás E, Blanchart K, Boignard A, Battistella P, Guendouz S, Houyel L, Para M, Flecher E, Gay A, Épailly É, Dambrin C, Lam K, Ka-Lai CH, Cho YH, Choi JO, Kim JJ, Coats L, Crossland DS, Mumford L, Hakmi S, Sivathasan C, Fabritz L, Schubert S, Gummert J, Hübler M, Jacksch P, Zuckermann A, Laufer G, Baumgartner H, Giamberti A, Reichenspurner H, Kirchhof P.ESC Heart Fail. 2021 Dec;8(6):5542-5550. doi: 10.1002/ehf2.13574. Epub 2021 Sep 12.PMID: 34510806

Cardiac and Pregnancy Outcomes of Pregnant Patients With Congenital Heart Disease According to Risk Classification System.

Steiner JM, Lokken E, Bayley E, Pechan J, Curtin A, Buber J, Albright C.Am J Cardiol. 2021 Dec 15;161:95-101. doi: 10.1016/j.amjcard.2021.08.037. Epub 2021 Oct 8.PMID: 34635313

Risk adjustment for cardiac surgery in adults with congenital heart disease: what do we know and what do we need to learn?

Jacobs JP, Nelson JS, Fuller S, Scholl FG, Kumar SR, Jacobs ML.Eur J Cardiothorac Surg. 2021 Dec 1;60(6):1405-1407. doi: 10.1093/ejcts/ezab266.PMID: 34448825 No abstract available.

Outcome and survival after open heart surgery for adults with congenital heart disease – a single center experience.

Fazlinović S, Wallinder A, Dellborg M, Furenäs E, Eriksson P, Synnergren M, Lidén H.Scand Cardiovasc J. 2021 Dec;55(6):345-353. doi: 10.1080/14017431.2021.1983639. Epub 2021 Oct 21.PMID: 34672849

Chronic Ventricular Assist Device Support in Adult Congenital Heart Disease Patients: A Children’s Hospital Perspective.

Perry T, Lorts A, Morales DLS, Fields K, Fahnhorst SE, Brandewie K, Lubert A, Villa CR.ASAIO J. 2021 Dec 1;67(12):e216-e220. doi: 10.1097/MAT.0000000000001595.PMID: 34711747

Lessons from the short- and mid-term outcome of medical rehabilitation in adults with congenital heart disease.

Freilinger S, Andric D, Andonian C, Beckmann J, Bongarth C, Einwang HP, Ewert P, Hofbeck M, Kaemmerer AS, Nagdyman N, Oberhoffer R, von Kodolitsch Y, Kaemmerer H, Neidenbach R.Cardiovasc Diagn Ther. 2021 Dec;11(6):1416-1431. doi: 10.21037/cdt-20-727.PMID: 35070810

German Registry for Cardiac Operations and Interventions in Patients with Congenital Heart Disease: Report 2020-Comprehensive Data from 6 Years of Experience.

Beckmann A, Dittrich S, Arenz C, Krogmann ON, Horke A, Tengler A, Meyer R, Bauer UMM, Hofbeck M; German Quality Assurance / Competence Network for Congenital Heart Defects Investigators.Thorac Cardiovasc Surg. 2021 Dec;69(S 03):e21-e31. doi: 10.1055/s-0041-1722978. Epub 2021 Feb 26.PMID: 33638137

Cognitive impairment in adult CHD survivors: A pilot study.

Rodriguez CP, Clay E, Jakkam R, Gauvreau K, Gurvitz M.Int J Cardiol Congenit Heart Dis. 2021 Dec;6:100290. doi: 10.1016/j.ijcchd.2021.100290. Epub 2021 Nov 27.PMID: 35425931

Risk evaluation in adult congenital heart surgery: analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database risk models on data from the European Congenital Heart Surgeons Association Congenital Database.

Pabst von Ohain J, Sarris G, Tobota Z, Maruszewski B, Vida VL, Hörer J.Eur J Cardiothorac Surg. 2021 Dec 1;60(6):1397-1404. doi: 10.1093/ejcts/ezab229.PMID: 34058002

Right Heart Dysfunction in Adults With Coarctation of Aorta: Prevalence and Prognostic Implications.

Egbe AC, Miranda WR, Jain CC, Connolly HM.Circ Cardiovasc Imaging. 2021 Dec;14(12):1100-1108. doi: 10.1161/CIRCIMAGING.121.013075. Epub 2021 Dec 8.PMID: 34875855

A Comprehensive Functional Analysis in Patients after Atrial Switch Surgery.

Hornung A, Vollmer D, Wiegand G, Apitz C, Latus H, Hofbeck M, Sieverding L.Thorac Cardiovasc Surg. 2021 Dec;69(S 03):e32-e40. doi: 10.1055/s-0041-1726307. Epub 2021 Apr 13.PMID: 33851400

The Fate of Congenitally Corrected Transposition of the Great Arteries Unoperated Before Adulthood.

Liu R, Pang K, Li S, Zhang B, Rui L, Lin Y, Wang C, Ma K.Ann Thorac Surg. 2021 Dec;112(6):2029-2037. doi: 10.1016/j.athoracsur.2020.10.025. Epub 2020 Nov 12.PMID: 33188752

Identification of metabolomic profile related to adult Fontan pathophysiology.

Motoki N, Motoki H, Utsumi M, Yamazaki S, Obinata H, Takei K, Yasukochi S.Int J Cardiol Heart Vasc. 2021 Nov 24;37:100921. doi: 10.1016/j.ijcha.2021.100921. eCollection 2021 Dec.PMID: 34901379

Non-invasive biomarkers of Fontan-associated liver disease.

Emamaullee J, Khan S, Weaver C, Goldbeck C, Yanni G, Kohli R, Genyk Y, Zhou S, Shillingford N, Sullivan PM, Takao C, Detterich J, Kantor PF, Cleveland JD, Herrington C, Ram Kumar S, Starnes V, Badran S, Patel ND.JHEP Rep. 2021 Sep 14;3(6):100362. doi: 10.1016/j.jhepr.2021.100362. eCollection 2021 Dec.PMID: 34693238

Endangered patients with congenital heart defect during transition-Germany-wide evaluation of medical data from National Register for Congenital Heart Defects (NRCHD).

Remmele J, Schiele S, Oberhoffer-Fritz R, Ewert P, Bauer UMM, Helm PC.Cardiovasc Diagn Ther. 2021 Dec;11(6):1284-1294. doi: 10.21037/cdt-21-66.PMID: 35070798

Tricuspid Valve Intervention at the Time of Pulmonary Valve Replacement in Adults With Congenital Heart Disease: A Systematic Review and Meta-Analysis.

Van den Eynde J, Callahan CP, Lo Rito M, Hussein N, Carvajal H, Guariento A, Ruhparwar A, Weymann A, Budts W, Gewillig M, Sá MP, Kutty S.J Am Heart Assoc. 2021 Dec 21;10(24):e022909. doi: 10.1161/JAHA.121.022909. Epub 2021 Dec 7.PMID: 34873914

Medical treatment of pulmonary hypertension in adults with congenital heart disease: updated and extended results from the International COMPERA-CHD Registry.

Kaemmerer AS, Gorenflo M, Huscher D, Pittrow D, Ewert P, Pausch C, Delcroix M, Ghofrani HA, Hoeper MM, Kozlik-Feldmann R, Skride A, Stähler G, Vizza CD, Jureviciene E, Jancauskaite D, Gumbiene L, Ewert R, Dähnert I, Held M, Halank M, Skowasch D, Klose H, Wilkens H, Milger K, Jux C, Koestenberger M, Scelsi L, Brunnemer E, Hofbeck M, Ulrich S, Vonk Noordegraaf A, Lange TJ, Bruch L, Konstantinides S, Claussen M, Löffler-Ragg J, Wirtz H, Apitz C, Neidenbach R, Freilinger S, Nemes A, Opitz C, Grünig E, Rosenkranz S.Cardiovasc Diagn Ther. 2021 Dec;11(6):1255-1268. doi: 10.21037/cdt-21-351.PMID: 35070795

Patient evaluation of a virtual visit program for adults with congenital heart disease.

Krishnamurthy Y, Pagliaro JA, Grady CB, Katz N, Bunn D, Bhatt AB.Am Heart J. 2021 Dec;242:138-145. doi: 10.1016/j.ahj.2021.08.004. Epub 2021 Aug 14.PMID: 34400141

Assessment of Current Society of Thoracic Surgeons Data Elements for Adults With Congenital Heart Disease.

Nelson JS, Jacobs JP, Bhamidipati CM, Yarboro LT, Kumar SR, McDonald D, Krohn C, Jones LA, Mayer JE, Scholl FG; STS ACHD Working Group.Ann Thorac Surg. 2021 Dec 11:S0003-4975(21)02045-2. doi: 10.1016/j.athoracsur.2021.11.017. Online ahead of print.PMID: 34906569

Outcome of pregnancy in a contemporary cohort of adults with congenital heart disease-a 10-year, single-center experience.

Toprak B, Govorov K, Kurz K, Csengeri D, Weimann J, Witte D, Hecher K, Hollwitz B, Hansen A, Rickers C, Magnussen C, von Kodolitsch Y, Zeller T, Blankenberg S, Sinning C, Kirchhof P, Zengin-Sahm E.Cardiovasc Diagn Ther. 2021 Dec;11(6):1344-1355. doi: 10.21037/cdt-20-650.PMID: 35070803

Iatrogenic Atrial Septal Defects Following Transcatheter Mitral Valve Repair and Implications of Interventional Closure.

Lurz P, Unterhuber M, Rommel KP, Kresoja KP, Kister T, Besler C, Fengler K, Sandri M, Daehnert I, Thiele H, Blazek S, von Roeder M.JACC Cardiovasc Interv. 2021 Dec 27;14(24):2685-2694. doi: 10.1016/j.jcin.2021.09.023.PMID: 34949392 Clinical Trial.

Catheter ablation in adult congenital heart disease on uninterrupted oral anticoagulation: Is it safe? Data from a large single-center study.

Foerschner L, Kriesmair J, Telishevska M, Kottmaier M, Bourier F, Reents T, Lengauer S, Lennerz C, Krafft H, Maurer S, Popa M, Kolb C, Deisenhofer I, Hessling G.Heart Rhythm. 2022 Apr;19(4):648-655. doi: 10.1016/j.hrthm.2021.12.018. Epub 2021 Dec 24.PMID: 34958942

Length of hospital stay after delivery among Danish women with congenital heart disease: a register-based cohort study.

Kirkegaard AM, Breckling M, Nielsen DG, Tolstrup JS, Johnsen SP, Ersbøll AK, Kloster S.BMC Pregnancy Childbirth. 2021 Dec 7;21(1):812. doi: 10.1186/s12884-021-04286-3.PMID: 34876061

The “Super-Fontan” Phenotype: Characterizing Factors Associated With High Physical Performance.

Tran DL, Celermajer DS, Ayer J, Grigg L, Clendenning C, Hornung T, Justo R, Davis GM, d’Udekem Y, Cordina R.Front Cardiovasc Med. 2021 Dec 7;8:764273. doi: 10.3389/fcvm.2021.764273. eCollection 2021.PMID: 34950712

Late Fontan failure in adult patients is predominantly associated with deteriorating ventricular function.

Sallmon H, Ovroutski S, Schleiger A, Photiadis J, Weber SC, Nordmeyer J, Berger F, Kramer P.Int J Cardiol. 2021 Dec 1;344:87-94. doi: 10.1016/j.ijcard.2021.09.042. Epub 2021 Sep 23.PMID: 34563595

Psychosocial Impact of Congenital Heart Diseases on Patients and Their Families: A Parent’s Perspective.

Jaschinski C, Knetsch V, Parzer P, Meyr J, Schroeder B, Fonseca E, Karck M, Kaess M, Loukanov T.World J Pediatr Congenit Heart Surg. 2022 Jan;13(1):9-15. doi: 10.1177/21501351211044127. Epub 2021 Dec 3.PMID: 34860617

Cone Reconstruction for Ebstein Anomaly: Ventricular Remodeling and Preliminary Impact of Stem Cell Therapy.

O’Leary PW, Qureshi MY, Cetta F, Nelson TJ, Holst KA, Dearani JA; Wanek Program Clinical Pipeline Group.Mayo Clin Proc. 2021 Dec;96(12):3053-3061. doi: 10.1016/j.mayocp.2021.02.015. Epub 2021 Sep 1.PMID: 34479739

A proposed strategy for anticoagulation therapy in noncompaction cardiomyopathy.

Chimenti C, Lavalle C, Magnocavallo M, Alfarano M, Mariani MV, Bernardini F, Della Rocca DG, Galardo G, Severino P, Di Lullo L, Miraldi F, Fedele F, Frustaci A.ESC Heart Fail. 2022 Feb;9(1):241-250. doi: 10.1002/ehf2.13694. Epub 2021 Dec 16.PMID: 34918480 Review.

Predictors of Poor Functional Status in Adult Fontan Patients Living at Moderate Altitude.

Stevens CG, Kay J, Pickett K, Campbell K, Khanna AD, Yeung E, Miyamoto SD, Jacobsen RM.Pediatr Cardiol. 2021 Dec;42(8):1757-1765. doi: 10.1007/s00246-021-02660-8. Epub 2021 Jun 18.PMID: 34143227

Prognostic Relevance of Thyroid Disorders in Adults With Congenital Heart Disease.

Fusco F, Scognamiglio G, Guarguagli S, Merola A, Palma M, Barracano R, Borrelli N, Correra A, Grimaldi N, Colonna D, Roma AS, Romeo E, Sarubbi B.Am J Cardiol. 2022 Mar 1;166:107-113. doi: 10.1016/j.amjcard.2021.11.017. Epub 2021 Dec 18.PMID: 34930612

Impact of the new UNOS donor heart allocation system on waitlist outcomes and early posttransplant mortality among adults with congenital heart disease.

Bravo-Jaimes K, Axsom K, Menachem J, Danford D, Kutty S, Cedars A.Am J Transplant. 2022 Apr;22(4):1123-1132. doi: 10.1111/ajt.16900. Epub 2021 Dec 23.PMID: 34859574

Surveillance of Fontan-associated liver disease: current standards and a proposal from the European Society of Paediatric Radiology Abdominal Task Force.

Perucca G, de Lange C, Franchi-Abella S, Napolitano M, Riccabona M, Ključevšek D, Toso S, Herrmann J, Stafrace S, Darge K, Damasio MB, Bruno C, Woźniak MM, Lobo L, Ibe D, Smets AM, Petit P, Ording Müller LS.Pediatr Radiol. 2021 Dec;51(13):2598-2606. doi: 10.1007/s00247-021-05173-x. Epub 2021 Oct 15.PMID: 34654967

Exercise capacity after total cavopulmonary anastomosis: a longitudinal paediatric and adult study.

Illinger V, Materna O, Slabý K, Jičínská D, Kovanda J, Koubský K, Pokorný J, Procházka M, Antonová P, Hoskovec A, Radvanský J, Chaloupecký V, Janoušek J.ESC Heart Fail. 2022 Feb;9(1):337-344. doi: 10.1002/ehf2.13747. Epub 2021 Dec 10.PMID: 34894102

Use of Pulmonary Arterial Hypertension Therapies in Patients with a Fontan Circulation: Current Practice Across the United Kingdom.

Constantine A, Dimopoulos K, Jenkins P, Tulloh RMR, Condliffe R, Jansen K, Chung NAY, Oliver J, Parry H, Fitzsimmons S, Walker N, Wort SJ, Papaioannou V, von Klemperer K, Clift P; CHAMPION steering committee members †.J Am Heart Assoc. 2022 Jan 4;11(1):e023035. doi: 10.1161/JAHA.121.023035. Epub 2021 Dec 20.PMID: 34927465

Pulmonary valve replacement may not restore ventricular volume and functional status in patients with pulmonary regurgitation after late tetralogy of Fallot repair.

Kim W, Kwak JG, Kwon HW, Cho S, Kim WH, Lee JR, Min J.Eur J Cardiothorac Surg. 2021 Dec 27;61(1):64-72. doi: 10.1093/ejcts/ezab277.PMID: 34254142

Cardiac MRI predictors of good long-term outcomes in patients with repaired TOF.

Majeed A, Geva T, Sleeper LA, Graf JA, Lu M, Babu-Narayan SV, Wald RM, Mulder BJM, Valente AM.Am Heart J. 2022 Mar;245:70-77. doi: 10.1016/j.ahj.2021.11.015. Epub 2021 Dec 4.PMID: 34875276

Role of Echocardiography for Assessment of Cardiac Remodeling in Congenitally Corrected Transposition of Great Arteries.

Egbe AC, Miranda WR, Connolly HM.Circ Cardiovasc Imaging. 2022 Jan;15(1):e013477. doi: 10.1161/CIRCIMAGING.121.013477. Epub 2021 Dec 28.PMID: 34961324

Outcomes following use of pediatric and young adult donor hearts with bicuspid aortic valves: A single-center case series.

Day P, Hope K, Puri K, Spinner J, Choudhry S, Tunuguntla H, Price J, Dreyer W, Denfield S.Pediatr Transplant. 2022 May;26(3):e14212. doi: 10.1111/petr.14212. Epub 2021 Dec 17.PMID: 34921483

Long-term Outcomes of Adults With Tricuspid Regurgitation Following Transcatheter Atrial Septal Defect Closure.

Bach Y, Abrahamyan L, Lee DS, Dharma C, Day J, Parker JD, Benson L, Osten M, Horlick E.Can J Cardiol. 2022 Mar;38(3):330-337. doi: 10.1016/j.cjca.2021.12.012. Epub 2021 Dec 30.PMID: 34974138

Long-Term Outcomes in Adult Patients With Pulmonary Hypertension After Percutaneous Closure of Atrial Septal Defects.

Akseer S, Abrahamyan L, Lee DS, Huszti E, Meier LM, Osten M, Benson L, Horlick E.Circ Cardiovasc Interv. 2022 Jan;15(1):e011110. doi: 10.1161/CIRCINTERVENTIONS.121.011110. Epub 2021 Dec 16.PMID: 34911355

Relation of Liver Volume to Adverse Cardiovascular Events in Adolescents and Adults With Fontan Circulation.

Lubert AM, Opotowsky AR, Palermo JJ, Alsaied T, Szugye C, Anwar N, Tiao GM, Lorts A, Dillman JR, Trout AT.Am J Cardiol. 2022 Feb 15;165:88-94. doi: 10.1016/j.amjcard.2021.10.045. Epub 2021 Dec 7.PMID: 34893302

Ventricular Function in Physiologically Repaired and Unrepaired Congenitally Corrected Transposition of the Great Arteries.

Wilson HC, Lu JC, Yu S, Lowery R, Mahani MG, Agarwal PP, Dorfman AL.Am J Cardiol. 2022 Feb 15;165:95-100. doi: 10.1016/j.amjcard.2021.11.011. Epub 2021 Dec 9.PMID: 34895701

High Variability of Right Ventricular Volumes and Function in Adults with Severe Pulmonary Regurgitation Late After Tetralogy of Fallot Repair.

Greutmann M, Ruperti J, Schwitz F, Haag N, Santos Lopes B, Meier L, Babic D, Valsangiacomo Buechel E, Kellenberger C, Bonassin F, Attenhofer Jost C, Schwerzmann M, Wustmann K, Tobler D.Am J Cardiol. 2022 Mar 1;166:88-96. doi: 10.1016/j.amjcard.2021.11.022. Epub 2021 Dec 20.PMID: 34949470

Circulatory Response to Rapid Volume Expansion and Cardiorespiratory Fitness in Fontan Circulation.

Möller T, Klungerbo V, Diab S, Holmstrøm H, Edvardsen E, Grindheim G, Brun H, Thaulow E, Köhn-Luque A, Rösner A, Døhlen G.Pediatr Cardiol. 2022 Apr;43(4):903-913. doi: 10.1007/s00246-021-02802-y. Epub 2021 Dec 17.PMID: 34921324

The Epidemiology of Persons Living with Fontan in 2020 and Projections for 2030: Development of an Epidemiology Model Providing Multinational Estimates.

Plappert L, Edwards S, Senatore A, De Martini A.Adv Ther. 2022 Feb;39(2):1004-1015. doi: 10.1007/s12325-021-02002-3. Epub 2021 Dec 22.PMID: 34936056

Radiologic follow-up in Fontan-associated liver disease in Europe: European Society of Paediatric Radiology survey demonstrates the need for a consensus protocol.

Perucca G, de Lange C, Franchi-Abella S, Napolitano M, Riccabona M, Ključevšek D, Toso S, Herrmann J, Stafrace S, Darge K, Damasio MB, Bruno C, Woźniak MM, Lobo L, Ibe D, Smets AM, Petit P, Müller LO.Pediatr Radiol. 2021 Dec;51(13):2607-2610. doi: 10.1007/s00247-021-05172-y. Epub 2021 Oct 16.PMID: 34654969