Pediatric Cardiology April 2022 Abstracts

The effect of dexmedetomidine on neuroprotection in pediatric cardiac surgery patients: study protocol for a prospective randomized controlled trial.

Ji SH, Kang P, Song IS, Jang YE, Lee JH, Kim JT, Kim HS, Kim EH.Trials. 2022 Apr 8;23(1):271. doi: 10.1186/s13063-022-06217-9.PMID: 35395776

Restriction of Atrial Septal Defect Leads to Growth of Hypoplastic Ventricle in Patients with Borderline Right or Left Heart.

Kwak JG, Del Nido PJ, Piekarski B, Marx G, Emani SM.Semin Thorac Cardiovasc Surg. 2022 Spring;34(1):215-223. doi: 10.1053/j.semtcvs.2021.03.039. Epub 2021 May 15.PMID: 34000428

Prediction of Bleeding in Pediatric Cardiac Surgery Using Clinical Characteristics and Prospective Coagulation Test Results.

Harris JM, Sheehan K, Rogers CA, Murphy T, Caputo M, Mumford AD.Semin Thorac Cardiovasc Surg. 2022 Spring;34(1):277-288. doi: 10.1053/j.semtcvs.2021.01.006. Epub 2021 Jan 12.PMID: 33444767

A Minimal Opioid Postoperative Management Protocol in Congenital Cardiac Surgery: Safe and Effective.

Frankel WC, Maul TM, Chrysostomou C, Wearden PD, Lowry AW, Baker KN, Nelson JS.Semin Thorac Cardiovasc Surg. 2022 Spring;34(1):262-272. doi: 10.1053/j.semtcvs.2020.12.001. Epub 2020 Dec 15.PMID: 33333164

Bi-level Positive Airway Pressure Versus Nasal CPAP for the Prevention of Extubation Failure in Infants After Cardiac Surgery.

Zheng YR, Lin WH, Lin SH, Xu N, Cao H, Chen Q.Respir Care. 2022 Apr;67(4):448-454. doi: 10.4187/respcare.09408. Epub 2022 Mar 8.PMID: 35260472 Clinical Trial.

Pulmonary hypertensive crisis in children with pulmonary arterial hypertension undergoing cardiac catheterization.

Li Q, Zhang C, Wang R, Keller BB, Gu H.Pulm Circ. 2022 Apr 18;12(2):e12067. doi: 10.1002/pul2.12067. eCollection 2022 Apr.PMID: 35514786

Pharmacogenomic study of anthracycline-induced cardiotoxicity in Mexican pediatric patients.

Vargas-Neri JL, Carleton B, Ross CJ, Medeiros M, Castañeda-Hernández G, Clark P.Pharmacogenomics. 2022 Apr;23(5):291-301. doi: 10.2217/pgs-2021-0144. Epub 2022 Feb 11.PMID: 35147047

Cell saver blood transfusions may be associated with a decrease in inflammation and improved outcome measures in pediatric cardiac surgery patients.

Martinez MJ, Schwingshackl A, Romero T, Roach GD, Belperio JA, Federman MD.Perfusion. 2022 Apr 12:2676591221078420. doi: 10.1177/02676591221078420. Online ahead of print.PMID: 35411827

Ventricular assist device support for children with chemotherapy-induced cardiomyopathy and advanced heart failure: Perspectives gained from a single-center experience.

Puri K, Denfield SW, Adachi I, Dreyer WJ, Price JF, Spinner JA, Choudhry S, Brackett J, Santucci G, Rainusso NC, Tunuguntla HP.Pediatr Transplant. 2022 Aug;26(5):e14286. doi: 10.1111/petr.14286. Epub 2022 Apr 26.PMID: 35474630

Comparison of UK paediatric SARS-CoV-2 admissions across the first and second pandemic waves.

Swann OV, Pollock L, Holden KA, Munro APS, Bennett A, Williams TC, Turtle L, Fairfield CJ, Drake TM, Faust SN, Sinha IP, Roland D, Whittaker E, Ladhani SN, Nguyen-Van-Tam JS, Girvan M, Donohue C, Donegan C, Spencer RG, Hardwick HE, Openshaw PJM, Baillie JK, Harrison EM, Docherty AB, Semple MG; ISARIC4C Investigators.Pediatr Res. 2022 Apr 22. doi: 10.1038/s41390-022-02052-5. Online ahead of print.PMID: 35449394

Outcome of Neonates Presenting With Severe Cardiac Failure due to Cerebral Arteriovenous Fistula.

Cornet MC, Li Y, Simmons RL, Baker A, Fullerton HJ, Hetts SW, Glass HC.Pediatr Neurol. 2022 Jun;131:25-29. doi: 10.1016/j.pediatrneurol.2022.04.006. Epub 2022 Apr 14.PMID: 35462109

Blood pressure variability during pediatric cardiac surgery is associated with acute kidney injury.

Fishbein JE, Barone M, Schneider JB, Meyer DB, Hagen J, Bakar A, Grammatikopoulos K, Sethna CB.Pediatr Nephrol. 2022 Apr;37(4):871-879. doi: 10.1007/s00467-021-05234-1. Epub 2021 Aug 26.PMID: 34436673

Acute Effects of Sodium Bicarbonate in Children with Congenital Heart Disease with Biventricular Circulation in Non-cardiac Arrest Situations.

Loomba RS, Villarreal EG, Dyamenahalli U, Farias JS, Flores S.Pediatr Cardiol. 2022 Apr 12. doi: 10.1007/s00246-022-02905-0. Online ahead of print.PMID: 35415814

Pressure-Strain Loops, a Novel Non-invasive Approach for Assessment of Children with Cardiomyopathy.

Aly DM, Nguyen M, Auerbach S, Rausch C, Landeck B 2nd, DiMaria MV.Pediatr Cardiol. 2022 Apr 11. doi: 10.1007/s00246-022-02902-3. Online ahead of print.PMID: 35403889

Autologous Cardiac Stem Cell Injection in Patients with Hypoplastic Left Heart Syndrome (CHILD Study).

Kaushal S, Hare JM, Shah AM, Pietris NP, Bettencourt JL, Piller LB, Khan A, Snyder A, Boyd RM, Abdullah M, Mishra R, Sharma S, Slesnick TC, Si MS, Chai PJ, Davis BR, Lai D, Davis ME, Mahle WT.Pediatr Cardiol. 2022 Apr 8. doi: 10.1007/s00246-022-02872-6. Online ahead of print.PMID: 35394149

Primary Disease, Sex, and Racial Differences in Health-Related Quality of Life in Adolescents and Young Adults with Heart Failure.

Cousino MK, Lim HM, Smith C, Yu S, Lowery R, Viers S, McCormick AD, Peng DM, Uzark K, Schumacher KR.Pediatr Cardiol. 2022 Apr 4:1-10. doi: 10.1007/s00246-022-02884-2. Online ahead of print.PMID: 35378609

Frequency of QTc Interval Prolongation in Children and Adults with Williams Syndrome.

Brink BD, Feinn R, Kozel BA, Billington CJ Jr, Liu D, Yu E, Sindhar S, He J, Rouse C, Lampert R, Pober BR, Elder RW.Pediatr Cardiol. 2022 Apr 2. doi: 10.1007/s00246-022-02883-3. Online ahead of print.PMID: 35366065

Coronary Interventions in Pediatric Congenital Heart Disease.

Schleiger A, Kramer P, Dreysse S, Schubert S, Peters B, Photiadis J, Berger F, Nordmeyer J.Pediatr Cardiol. 2022 Apr;43(4):769-775. doi: 10.1007/s00246-021-02784-x. Epub 2021 Dec 13.PMID: 34902048

Long-Term Follow-Up of Pediatric Patients with Severe Postoperative Pulmonary Hypertension After Correction of Congenital Heart Defects.

Lindberg L.Pediatr Cardiol. 2022 Apr;43(4):827-836. doi: 10.1007/s00246-021-02794-9. Epub 2021 Dec 6.PMID: 34873634

Efficacy of Short-Term Oral Prednisolone Treatment in the Management of Pericardial Effusion Following Pediatric Cardiac Surgery.

Mizumoto M, Masaki N, Sai S.Pediatr Cardiol. 2022 Apr;43(4):764-768. doi: 10.1007/s00246-021-02783-y. Epub 2021 Dec 1.PMID: 34853877

Utility of Exercise Stress Testing in Pediatric Patients with T-Wave Inversions.

Gupta A, Bansal N, Jour LS, Clark BC.Pediatr Cardiol. 2022 Apr;43(4):713-718. doi: 10.1007/s00246-021-02776-x. Epub 2021 Nov 25.PMID: 34820701

Acute Rheumatic Fever and Rheumatic Heart Disease: Highlighting the Role of Group A Streptococcus in the Global Burden of Cardiovascular Disease.

Auala T, Zavale BG, Mbakwem AÇ, Mocumbi AO.Pathogens. 2022 Apr 21;11(5):496. doi: 10.3390/pathogens11050496.PMID: 35631018 Review.

Diagnostic validity and clinical utility of genetic testing for hypertrophic cardiomyopathy: a systematic review and meta-analysis.

Christian S, Cirino A, Hansen B, Harris S, Murad AM, Natoli JL, Malinowski J, Kelly MA.Open Heart. 2022 Apr;9(1):e001815. doi: 10.1136/openhrt-2021-001815.PMID: 35387861

Postoperative Chylothorax in Neonates and Infants after Congenital Heart Disease Surgery-Current Aspects in Diagnosis and Treatment.

Samanidis G, Kourelis G, Bounta S, Kanakis M.Nutrients. 2022 Apr 26;14(9):1803. doi: 10.3390/nu14091803.PMID: 35565771 Review.

Cardiovascular Magnetic Resonance for Patients With COVID-19.

Petersen SE, Friedrich MG, Leiner T, Elias MD, Ferreira VM, Fenski M, Flamm SD, Fogel M, Garg R, Halushka MK, Hays AG, Kawel-Boehm N, Kramer CM, Nagel E, Ntusi NAB, Ostenfeld E, Pennell DJ, Raisi-Estabragh Z, Reeder SB, Rochitte CE, Starekova J, Suchá D, Tao Q, Schulz-Menger J, Bluemke DA.JACC Cardiovasc Imaging. 2022 Apr;15(4):685-699. doi: 10.1016/j.jcmg.2021.08.021. Epub 2021 Oct 13.PMID: 34656482 Review.

Diagnostic yield and cost analysis of electrocardiographic screening in Swiss paediatric athletes.

Albiński M, Saubade M, Menafoglio A, Meyer P, Capelli B, Perrin T, Trachsel L, Hagemeyer D, Casagrande D, Wilhelm M, Benaim C, Pirrello T, Albrecht S, Schmied C, Mivelaz Y, Tercier S, Baggish A, Gabus V.J Sci Med Sport. 2022 Apr;25(4):281-286. doi: 10.1016/j.jsams.2021.11.039. Epub 2021 Nov 18.PMID: 34895837 Free article.

The Clinical and Cost Utility of Cardiac Catheterizations in Infants with Bronchopulmonary Dysplasia.

Yang EL, Levy PT, Critser PJ, Dukhovny D, Evers PD.J Pediatr. 2022 Jul;246:56-63.e3. doi: 10.1016/j.jpeds.2022.04.009. Epub 2022 Apr 14.PMID: 35430250

Partnering With Stakeholders to Inform the Co-Design of a Psychosocial Intervention for Prenatally Diagnosed Congenital Heart Disease.

Sood E, Gramszlo C, Perez Ramirez A, Braley K, Butler SC, Davis JA, Divanovic AA, Edwards LA, Kasparian N, Kelly SL, Neely T, Ortinau CM, Riegel E, Shillingford AJ, Kazak AE.J Patient Exp. 2022 Apr 20;9:23743735221092488. doi: 10.1177/23743735221092488. eCollection 2022.PMID: 35493441

Machine-learning-based exploration to identify remodeling patterns associated with death or heart-transplant in pediatric-dilated cardiomyopathy.

Garcia-Canadilla P, Sanchez-Martinez S, Martí-Castellote PM, Slorach C, Hui W, Piella G, Aguado AM, Nogueira M, Mertens L, Bijnens BH, Friedberg MK.J Heart Lung Transplant. 2022 Apr;41(4):516-526. doi: 10.1016/j.healun.2021.11.020. Epub 2021 Dec 5.PMID: 35063339 Free article.

Doppler Echocardiographic Features of Pulmonary Vein Stenosis in Ex-Preterm Children.

Lin Y, Amin EK, Keller RL, Teitel DF, Nawaytou HM.J Am Soc Echocardiogr. 2022 Apr;35(4):435-442. doi: 10.1016/j.echo.2021.12.015. Epub 2022 Jan 2.PMID: 34986343

Impact of Right Ventricular Pressure Load After Repair of Tetralogy of Fallot.

Latus H, Stammermann J, Voges I, Waschulzik B, Gutberlet M, Diller GP, Schranz D, Ewert P, Beerbaum P, Kühne T, Sarikouch S; German Competence Network for Congenital Heart Defects Investigators *.J Am Heart Assoc. 2022 Apr 5;11(7):e022694. doi: 10.1161/JAHA.121.022694. Epub 2022 Mar 18.PMID: 35301850

Adherence With Lipid Screening Guidelines in Children With Acquired and Congenital Heart Disease: An Observational Study Using Data From The MarketScan Commercial and Medicaid Databases.

Berger JH, Faerber JA, Chen F, Lin KY, Brothers JA, O’Byrne ML.J Am Heart Assoc. 2022 Apr 5;11(7):e024197. doi: 10.1161/JAHA.121.024197. Epub 2022 Mar 18.PMID: 35301862

Use of Photovoice to Explore Pediatric Patients with Hypertrophic Cardiomyopathy and their Parents’ Perceptions of a Heart-Healthy Lifestyle.

Sobierajski F, Storey K, Bird M, Anthony S, Pol S, Pidborochynski T, Balmer-Minnes D, Tharani AR, Power A, Khoury M, Cunningham C, Jeewa A, Conway J.J Am Heart Assoc. 2022 Apr 5;11(7):e023572. doi: 10.1161/JAHA.121.023572. Epub 2022 Mar 18.PMID: 35301849

Advances in Managing Transition to Adulthood for Adolescents With Congenital Heart Disease: A Practical Approach to Transition Program Design: A Scientific Statement From the American Heart Association.

John AS, Jackson JL, Moons P, Uzark K, Mackie AS, Timmins S, Lopez KN, Kovacs AH, Gurvitz M; American Heart Association Adults With congenital Heart Disease Committee of the Council on Lifelong congenital Heart Disease and Heart Health in the Young and the Council on Clinical Cardiology; Council on Cardiovascular and Stroke Nursing; Council on Arteriosclerosis, Thrombosis and Vascular Biology; and Stroke Council.J Am Heart Assoc. 2022 Apr 5;11(7):e025278. doi: 10.1161/JAHA.122.025278. Epub 2022 Mar 17.PMID: 35297271 Review.

Outcomes of pregnancy in women with hypertrophic cardiomyopathy: A systematic review.

Moolla M, Mathew A, John K, Yogasundaram H, Alhumaid W, Campbell S, Windram J.Int J Cardiol. 2022 Jul 15;359:54-60. doi: 10.1016/j.ijcard.2022.04.034. Epub 2022 Apr 12.PMID: 35427704

Pediatric heart transplantation in infants and small children under 3 years of age: Single center experience – “Early and long-term results”.

Rosenthal LL, Ulrich SM, Zimmerling L, Brenner P, Müller C, Michel S, Hörer J, Netz H, Haas NA, Hagl C.Int J Cardiol. 2022 Jun 1;356:45-50. doi: 10.1016/j.ijcard.2022.04.002. Epub 2022 Apr 5.PMID: 35395286

Relationship between life-threatening events and electromechanical window in patients with hypertrophic cardiomyopathy: A novel parameter for risk stratification of sudden cardiac death.

Song MK, Baek SM, Kim GB, Lee SY, Kwon HW, Lee HJ, Choi YJ, Kim HK, Bae EJ.Heart Rhythm. 2022 Apr;19(4):588-594. doi: 10.1016/j.hrthm.2021.12.016. Epub 2021 Dec 18.PMID: 34933113

Incidence of life-threatening events in children with Wolff-Parkinson-White syndrome: Analysis of a large claims database.

Janson CM, Millenson ME, Okunowo O, Dai D, Christmyer Z, Tan RB, Ramesh Iyer V, Shah MJ, O’Byrne ML.Heart Rhythm. 2022 Apr;19(4):642-647. doi: 10.1016/j.hrthm.2021.12.009. Epub 2021 Dec 10.PMID: 34902591

Developmental changes in cardiac expression of KCNQ1 and SCN5A spliceoforms: Implications for sudden unexpected infant death.

Williams AF, Bryan AF, Tomasek K, Fulmer CA, Gregory K, Bozeman C, Li F, Absi TS, Su YR, Kannankeril PJ.Heart Rhythm. 2022 Apr;19(4):667-673. doi: 10.1016/j.hrthm.2021.11.031. Epub 2021 Nov 26.PMID: 34843966

Myocarditis following COVID-19 vaccination in adolescents and adults: a cumulative experience of 2021.

Ilonze OJ, Guglin ME.Heart Fail Rev. 2022 Apr 22:1-11. doi: 10.1007/s10741-022-10243-9. Online ahead of print.PMID: 35449353 Review.

Endocardial Radiofrequency Ablation vs. Septal Myectomy in Patients With Hypertrophic Obstructive Cardiomyopathy: A Systematic Review and Meta-Analysis.

Jiang T, Huang B, Huo S, Mageta LM, Guo J, Lv J, Lin L.Front Surg. 2022 Apr 26;9:859205. doi: 10.3389/fsurg.2022.859205. eCollection 2022.PMID: 35558385

Real-World Use of Carvedilol in Children With Dilated Cardiomyopathy: Long-Term Effect on Survival and Ventricular Function.

Adorisio R, Cantarutti N, Ciabattini M, Amodeo A, Drago F.Front Pediatr. 2022 Apr 1;10:845406. doi: 10.3389/fped.2022.845406. eCollection 2022.PMID: 35433536

Automatic Detection of Secundum Atrial Septal Defect in Children Based on Color Doppler Echocardiographic Images Using Convolutional Neural Networks.

Hong W, Sheng Q, Dong B, Wu L, Chen L, Zhao L, Liu Y, Zhu J, Liu Y, Xie Y, Yu Y, Wang H, Yuan J, Ge T, Zhao L, Liu X, Zhang Y.Front Cardiovasc Med. 2022 Apr 6;9:834285. doi: 10.3389/fcvm.2022.834285. eCollection 2022.PMID: 35463790 Free PMC article

Follow-up cardiac magnetic resonance in children with vaccine-associated myocarditis.

Hadley SM, Prakash A, Baker AL, de Ferranti SD, Newburger JW, Friedman KG, Dionne A.Eur J Pediatr. 2022 Jul;181(7):2879-2883. doi: 10.1007/s00431-022-04482-z. Epub 2022 Apr 28.PMID: 35482094

Predictors of severe illness in children with multisystem inflammatory syndrome after SARS-CoV-2 infection: a multicentre cohort study.

Merckx J, Cooke S, El Tal T, Bitnun A, Morris SK, Yeh EA, Yea C, Gill P, Papenburg J, Lefebvre MA, Scuccimarri R, Ulloa-Gutierrez R, Brenes-Chacon H, Yock-Corrales A, Ivankovich-Escoto G, Soriano-Fallas A, Mezerville MH, Dewan T, Restivo L, Nateghian A, Aski BH, Manafi A, Dwilow R, Bullard J, Lopez A, Sadarangani M, Roberts A, Barton M, Petel D, Le Saux N, Bowes J, Purewal R, Lautermilch J, Tehseen S, Bayliss A, Wong JK, Leifso K, Foo C, Robinson J; Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC).CMAJ. 2022 Apr 11;194(14):E513-E523. doi: 10.1503/cmaj.210873.PMID: 35410860

SARS-CoV-2 Infection and Associated Cardiovascular Manifestations and Complications in Children and Young Adults: A Scientific Statement From the American Heart Association.

Jone PN, John A, Oster ME, Allen K, Tremoulet AH, Saarel EV, Lambert LM, Miyamoto SD, de Ferranti SD; American Heart Association Leadership Committee and Congenital Cardiac Defects Committee of the Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Hypertension, and Council on Peripheral Vascular Disease.Circulation. 2022 May 10;145(19):e1037-e1052. doi: 10.1161/CIR.0000000000001064. Epub 2022 Apr 11.PMID: 35400169 Free article. Review.

Diastolic Blood Pressure Alleles Improve Congenital Heart Defect Repair Outcomes.

Breeyear JH, Keaton JM, Torstenson ES, Smith AH, Klarin D, Damrauer SM, Natarajan P, Van Driest SL, Weiner JG, Kannankeril PJ, Edwards TL.Circ Res. 2022 Apr;130(7):1030-1037. doi: 10.1161/CIRCRESAHA.121.319842. Epub 2022 Feb 24.PMID: 35199555

Neonatal Myocardial Infarction: A Proposed Algorithm for Coronary Arterial Thrombus Management.

El-Sabrout H, Ganta S, Guyon P, Ratnayaka K, Vaughn G, Perry J, Kimball A, Ryan J, Thornburg CD, Tucker S, Mo J, Hegde S, Nigro J, El-Said H.Circ Cardiovasc Interv. 2022 May;15(5):e011664. doi: 10.1161/CIRCINTERVENTIONS.121.011664. Epub 2022 Apr 29.PMID: 35485231 Review.

Clinical efficacy and safety of selexipag in children and young adults with idiopathic and heritable pulmonary arterial hypertension.

Takatsuki S, Nakayama T, Shimizu Y, Kawai R, Matsuura H.Cardiol Young. 2022 Apr 6:1-5. doi: 10.1017/S1047951122000415. Online ahead of print.PMID: 35383553

Machine learning predicts blood lactate levels in children after cardiac surgery in paediatric ICU.

Sughimoto K, Levman J, Baig F, Berger D, Oshima Y, Kurosawa H, Aoki K, Seino Y, Ueda T, Liu H, Miyaji K.Cardiol Young. 2022 Apr 4:1-8. doi: 10.1017/S1047951122000932. Online ahead of print.PMID: 35373725

Variation in hospital costs and resource utilisation after congenital heart surgery.

Blinder JJ, Huang YS, Rossano JW, Costarino AT, Li Y.Cardiol Young. 2022 Apr 4:1-12. doi: 10.1017/S1047951122001019. Online ahead of print.PMID: 35373722

The use of steroids in treating chylothorax following cardiac surgery in children: a unique perspective.

Saad D, Makarem A, Fakhri G, Al Amin F, Bitar F, El Rassi I, Arabi M.Cardiol Young. 2022 Apr 1:1-6. doi: 10.1017/S1047951122000750. Online ahead of print.PMID: 35361290 Review.

Feeding outcomes in post-discharge feeding clinic for infants following cardiac surgery.

Jones C, Winder M, Ou Z, Miller TA, Malik L, Flannery M, Glotzbach K.Cardiol Young. 2022 Apr;32(4):628-635. doi: 10.1017/S1047951121002833. Epub 2021 Jul 26.PMID: 34304751

Adolescents and adults with Fontan circulation: insights from the PREpArE-Fontan registry.

Søndergaard L, Aboulhosn J, d’Udekem Y, Faure C, Franklin WJ, Hager A, Kim YY, Muros-Le Rouzic E, Rosenberg D, Schwerzmann M, Clift P.Cardiol Young. 2022 Apr;32(4):597-605. doi: 10.1017/S1047951121002791. Epub 2021 Jul 23.PMID: 34294186 Free article.

Beta-blocker use after complete repair of tetralogy of Fallot: an analysis of a national database.

Villarreal EG, Farias JS, Tweddell JS, Loomba RS, Flores S.Cardiol Young. 2022 Apr;32(4):584-588. doi: 10.1017/S1047951121002638. Epub 2021 Jul 8.PMID: 34233773

Prescription of cardiovascular medication in children with congenital heart defects across six European Regions from 2000 to 2014: data from the EUROlinkCAT population-based cohort study.

Damkjaer M, Urhoj SK, Tan J, Briggs G, Loane M, Given JE, Barrachina-Bonet L, Cavero-Carbonell C, Coi A, Neville AJ, Heino A, Kiuru-Kuhlefelt S, Jordan S, Scanlon I, Pierini A, Puccini A, Garne E, Morris JK.BMJ Open. 2022 Apr 21;12(4):e057400. doi: 10.1136/bmjopen-2021-057400.PMID: 35450908

Technology landscape of pediatric mechanical circulatory support devices: A systematic review 2010-2021.

Palazzolo T, Hirschhorn M, Garven E, Day S, Stevens RM, Rossano J, Tchantchaleishvili V, Throckmorton AL.Artif Organs. 2022 Aug;46(8):1475-1490. doi: 10.1111/aor.14242. Epub 2022 Apr 14.PMID: 35357020 Review.